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Polymorphism in Cytochrome P4501A1 is Significantly Associated with Head and Neck Cancer Risk
Cancer Investigation, 09/22/09
Singh AP et al. – The HNSCC risk also increased several folds in cases with combination of variant genotypes of CYP1A1*2A or CYP1A1*2C with null genotype of glutathione–S–transferase M1 (GSTM1), a phase II enzyme, particularly in cases who were tobacco users (smokers and tobacco chewers), demonstrating the role of gene–gene and gene–environment interactions in the development of HNSCC.
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