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See Latest ArticlesFunctional genome screen for therapeutic targets of osteosarcoma
Cancer Science, 09/24/09
Yamaguchi U et al. – Different constructs of siRNA specifically targeting polo–like 1 kinase (PLK1) significantly caused mitotic cell cycle arrest and subsequent apoptotic cell death in a variety of OS cell lines. siRNA targeting PLK1 also suppressed the growth of OS xenografts established in immunodeficient mice. Recently, phase I clinical trials of PLK1 chemical inhibitors have been reported. The results indicate that PLK1 is a promising molecular target for pharmacologic intervention in OS.
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Today in Basic Science/Genetics...keeping you current
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Mutation analysis of the MSMB gene in familial prostate cancer
British Journal of Cancer, 12/10/09
Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer
British Journal of Cancer, 12/10/09
Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells
British Journal of Cancer, 12/10/09
Today in Bone/Cartilage...keeping you current
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Antitumor Efficacy of Two Novel Non-Thiazolidinedione Compounds as Peroxisome Proliferator-Activated Receptor-gamma Agonists in Human Osteosarcoma Cells in vitro
Chemotherapy, 12/10/09
EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma
Cancer Research, 12/10/09
Malignancy as a Possible Complication of Complex Regional Pain Syndrome: A Case Report
Pain Medicine, 12/10/09
Today in Pharmacology/Therapy...keeping you current
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18FDG-PET-CT in the follow-up of non-small cell lung cancer patients after radical radiotherapy with or without chemotherapy: An economic evaluation
European Journal of Cancer, 12/10/09
MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types
European Journal of Cancer, 12/10/09
Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies
European Journal of Cancer, 12/10/09
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