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Variation in vascular distribution in small lung cancers
Lung Cancer, 09/14/09

Zhang L et al. –These results suggest that tumor vessels experience a continuous temporal and spatial remodeling as tumors grow and that bigger tumors tend to have fewer but larger blood vessels. On average, squamous- or large-cell carcinomas have a larger average vessel diameter as compared with adenocarcinomas and that the vasculature of an adenocarcinoma might remodel as the % BAC decreases. The overall proportion of tumor volume comprised of vessels 200?m or larger is small and unlikely to influence overall tumor volume and doubling time estimates.

Methods

105 resected NSCLC
No pathologic evidence of vascular, lymphatic, bronchial, or pleural invasion
% BAC of all adenocarcinomas was determined by a pulmonary pathologist
Representative histology slide of each carcinoma digitally scanned and the number of blood vessels (#V) with at least a diameter of 200?m was identified
CT consistency of cancers was also recorded as non-solid (NS), part-solid (PS) and solid

Results

Number of blood vessels per cm2 of tumor area was higher for adenocarcinoma as compared with large- and squamous-cell carcinoma
For adenocarcinoma, #V/TA decreased with decreasing % BAC
Ratio of the total vascular area to tumor area (VA/TA) did not differ significantly by cell type nor for the adenocarcinoma by % BAC
#V/TA decreased from 9.6 for non-solid nodules, to 7.5 for part solid nodules and to 5.1 for solid nodules
No significant difference in the VA/TA ratio by nodule consistency
VA comprised 2.7% of the total tumor area (TA) for 105 cancers

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