Oncology Medical News about keratoacanthoma

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Immunoexpression of Bcl-x in squamous cell carcinoma and keratoacanthoma: differences in pattern and correlation with pathobiology
Histopathology, 09/04/09

Tan K–B et al. – The results provide some insight into the pathobiology of SCC and KA. The generally diffuse and stronger Bcl–x immunoreactivity in SCC suggests that the protein contributes to the survival advantage and aggressiveness of the tumour. In KA, the preferential reactivity of the mid–to–upper neoplastic keratinocytes can plausibly be explained by such differentiated cells attempting to prolong their existence under rapidly evolving circumstances, whereas the reduced reactivity in regressing KA is consistent with the end stage of the tumour.

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