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Active MMP-2 effectively identifies the presence of colorectal cancer
International Journal of Cancer, 09/15/09

Murnane MJ et al. – Fully active MMP–2 is expressed at such low levels in human tissues that studies often fail to confirm its value as a cancer marker despite strong associations with malignancy. Receiver operating characteristic (ROC) curves demonstrated that a cut–off for active MMP–2 of >44 SDU activity/mg soluble protein (>180 pg/mg), which is three times mean normal levels, would permit detection of colorectal cancer with an estimated sensitivity of 84% and estimated specificity of 93%.

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