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Wei EK et al. – There was increased risk for a positive family history of colon or rectal cancer (55%), 10 or more pack–years of cigarette smoking before age 30 years (16%), and tallness (67 inches (170 cm) vs. 61 inches (155 cm): 19%). Reduced risk was observed for current postmenopausal hormone use (–23%), being physically active (21 metabolic equivalent (MET)–hours/week vs. 2 MET–hours/week: –49%), taking aspirin (7 tablets/week vs. none: –29%), and being screened (–24%). Women who smoked, had a consistently high relative weight, had a low physical activity level, consumed red or processed meat daily, were never screened, and consumed low daily amounts of folate had almost a 4–fold higher cumulative risk of colon cancer by age 70 years. For women with a high risk factor profile, adopting a healthier lifestyle could dramatically reduce colon cancer risk.


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