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See Latest ArticlesInhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors
Cancer Research, 09/03/09
Muhlenberg T et al. – Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or platelet–derived growth factor receptor A (PDGFRA), and treatment with the tyrosine kinase inhibitor imatinib yields responses in the majority of patients. The results provide preclinical evidence for a disease–specific effect of HDACI in KIT–positive GIST, which could translate into therapeutic activity.
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Today in Basic Science/Genetics...keeping you current
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Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal-type
Blood, 12/09/09
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome
Blood, 12/09/09
TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway
Oncogene, 12/09/09
Today in GI Oncology...keeping you current
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Is temperature an effect modifier of the association between green tea intake and gastric cancer risk
European Journal of Cancer Prevention, 12/09/09
Tobacco, alcohol and tea drinking as risk factors for esophageal cancer: A case-control study from Mumbai, India
Cancer Epidemiology, 12/09/09
Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines
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