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Survival and prognostic factors in a series of adults with medulloblastomas
Journal of Neurosurgery, 09/08/09

Riffaud L et al. – Long-term survival is possible in adults treated for medulloblastoma. Metastasis seeding at presentation is a poor prognostic factor.

Methods

27 patients ≥ 16 y/o

Results

5- and 10-y survival rates were 81% and 62%, respectively
Median OS was 17.7 y
5- and 10-y event-free survival were 72% and 57%, respectively
Median event-free survival time was 17.9 y
Survival was correlated with female gender and M stage
11/27 patients had a recurrence at a median time of 4.2 y
The posterior fossa was the most common site of recurrence
Median survival time after dx of recurrence was 2.5 y; 100% mortality rate despite aggressive tx

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