Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesDual Inhibition of Mitogen-Activated Protein Kinase Kinase and Mammalian Target of Rapamycin in Differentiated and Anaplastic Thyroid Cancer
Journal of Clinical Endocrinology and Metabolism, 09/03/09
Jin N et al. – Differentiated thyroid cancer and anaplastic thyroid cancer tumors frequently have activation of the ras/raf /MAPK kinase (MEK)/ERK and phosphatidylinositol 3–kinase (PI–3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathways. The preclinical results support the inclusion of thyroid cancer patients in early–phase clinical trials combining ras/RAF/MEK/ERK and PI–3K/AKT/mTOR pathway inhibition.
Related Articles
Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
Journal of Dermatological Science, 10/06/09
Relevance Score: 91%
Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs
Nephrology Dialysis Transplantation, 11/17/09
Relevance Score: 89%
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis
International Journal of Cancer, 11/10/09
Relevance Score: 88%
Rapamycin as a Therapy of Choice After Renal Transplantation in a Patient With Tuberous Sclerosis Complex
Transplantation Proceedings, 11/20/09
Relevance Score: 87%
MYC Activity Mitigates Response to Rapamycin in Prostate Cancer through Eukaryotic Initiation Factor 4E–Binding Protein 1–Mediated Inhibition of Autophagy
Cancer Research, 10/06/09
Relevance Score: 87%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer
Cancer Treatment Reviews, 12/04/09
Dysregulation of Platelet-Derived Growth Factor beta-Receptor Expression by deltaNp73 in Neuroblastoma
Molecular Cancer Research, 12/04/09
Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression
Virchows Archiv, 12/04/09
Today in Endocrine Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimotos thyroiditis
Histopathology, 12/04/09
Oncocytic versus mitochondrion-rich follicular thyroid tumours: should we make a difference
Histopathology, 12/04/09
Clinical inquiry: What's the best way to monitor low-risk patients with a history of differentiated thyroid cancer?
The Journal of Family Practice, 12/03/09
Sponsor
Article Search
Sponsor
Sponsor