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Cell viability during platelet storage in correlation to cellular metabolism after different pathogen reduction technologies
Transfusion, 09/09/09
Picker SM et al. – PRT treatment using M increased both anoxidative glycolytic flux and oxidative phosphorylation. The I–based technique was associated with an impaired mitochondria–based respiration. During terminal storage, this resulted in significantly lower maintenance of ATP and cell viability. The impact of these findings for storage prolongation or clinical use must await further evaluation.
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