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See Latest ArticlesStudies of the anti–platelet factor 4/heparin immune response: adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens
Transfusion, 09/04/09
Selleng K et al. – HIT lacks a strong memory B–cell response, perhaps explaining transience and lack of anamnesis of the anti–PF4/heparin immune response. The technical modifications we describe for the ELISPOT assay, which permit detection of B–cell reactions to complex antigens, could be useful for studying other immunohematologic disorders, for example, drug–dependent thrombocytopenia and acquired hemophilia.
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