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Zolnierek J et al. – Pre–existing metastatic bone lesions were reported in 82 patients, of which 30 experienced progression. Twenty–three of 210 patients developed new bone lesions. Overall, sunitinib appeared slightly more effective than sorafenib or IFN–alfa at extending mean time to progression of pre–existing bone lesions. Compared with sorafenib, sunitinib significantly decreased formation and prolonged time to occurrence of new bone lesions.


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