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Ovarian cancer cells stimulate uPA gene expression in fibroblastic stromal cells via multiple paracrine and autocrine mechanisms
Gynecologic Oncology, 09/01/09
Noskova V et al. – The authors identified two cytokines as paracrine signals, and five cytokines as autocrine signals in ovarian cancer cell induced up–regulation of uPA mRNA in stromal fibroblastic cells. It is crucial to understand intra–tumoral cross–talk, since it can offer new therapeutic approaches.
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