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See Latest ArticlesCorrelation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type
Modern Pathology, 08/31/09
Torres–Cabala CA et al. – Immunohistochemical expression of KIT in less than 10% of the cells of the invasive component of acral lentiginous/mucosal melanomas appears to be a strong negative predictor of KIT mutation and therefore can potentially be used to triage cases for additional KIT genotyping.
Dr CA Torres-Cabala, 09/08/09
| This is the largest series of acral-lentiginous/mucosal melanoma evaluated for KIT mutation status and KIT protein expression to date. 15% of the acral-lentiginous/mucosal melanoma cases, including metastases, showed a mutation in KIT. Our results expand the current knowledge on KIT status in melanoma and support the use of tyrosine kinase inhibitors in selected cases. |
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