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Interval to testosterone recovery after hormonal therapy for prostate cancer and risk of death
International Journal of Radiation Oncology*Biology*Physics, 09/01/09
D'Amico AV et al. – A longer TTR after RT plus 6 months of HT for unfavorable-risk PCa is associated with a lower risk of death in men with no or minimal comorbidity.
Methods- 206 men with localized, unfavorable risk PCa were randomized to RT or RT + 6 mos HT
- Of the 102 men randomized to receive RT and HT, 57 (56%) had a TTR of >2 years, and none of these men had died of PCa after a median follow-up of 7.6 years.
- As the TTR increased, the risk of death decreased significantly.
- The survival estimates were similar across the TTR values in men with moderate to severe comorbidity; however, these estimates increased significantly with decreasing PCa-specific mortality as the TTR increased in men with no or minimal comorbidity.
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