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An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma
American Journal of Hematology, 09/01/09
Vij R et al. – Denosumab treatment of patients with relapsed or plateau-phase multiple myeloma achieved SD status within 3 mos.
Methods- Monthly doses of denosumab until ds progression
- Denosumab inhibited the RANKL pathway
- 21% of patients with relapsed myeloma achieved SD for 16.5 mos within 3 mos of tx
- 46% of patients with plateau-phase myeloma achieved SD for 18.3 mos within 3 mos of tx
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