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Loss of RKIP expression is associated with poor survival in GISTs
Virchows Archiv, 08/31/09
Martinho O et al. – Loss of RKIP expression cold have an important role as a prognostic marker in GISTSs.
Methods- RKIP expression levels in 70 GISTs
- RKIP was not expressed in 9% of GISTs
- Loss of RKIP expression was not due to promoter methylation as assessed by methylation-specific PCR
- Loss of RKIP expression was associated with poor DSS and tumor necrosis in GISTs
- RKIP expression was associated with absence of metastasis
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