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Serum osteopontin levels are highly prognostic for survival in advanced non-small cell lung cancer: results from JMTO LC 0004
Journal of Thoracic Oncology, 09/03/09
Isa S-L et al. – Low OPN serum levels are significantly associated with a favorable prognosis for NSCLC.
Methods- Prospective, randomized phase III trial comparing tx of advanced NSCLC with paclitaxel + carboplatin vs. vinorelbine and gemcitabine followed by docetaxel
- 20 ml of blood was collected from 71 patients (PC arm, n=32; VGD arm, n=39) before tx and tested for OPN and bFGF
- Low OPN levels correlated with better OS and PFS
- High bFGF levels correlated with better OS
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