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Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma
Human Pathology, 08/25/09
Kalinski T et al. – As EFNA5 down–regulation is a consistent finding in chondrosarcomas, the authors presume that it represents another essential alteration in tumorigenesis and tumor progression associated with cell adhesion, in addition to a multitude of other partially unknown biologic functions mediated by bidirectional ephrin/Eph receptor signaling and cross talk.
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Today in Basic Science/Genetics...keeping you current
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Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia
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