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Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
BMC Cancer, 08/26/09

Tuhkanen H et al. – Nuclear Snail1 expression is related to tumor progression, and expression in borderline tumors indicates a role for Snail1 in early epithelial ovarian tumor development.

Methods

Epithelial and stromal fibroblast-like fusiform cells of 14 normal ovarian samples, 21 benign, 24 borderline, and 74 malignant epithelial ovarian tumors for Snail1 protein using immunohistochemistry

Results

Nuclei of surface peritoneal cells of normal ovaries were negative for Snail1
Nuclear expression of Snail1 protein in epithelial ovarian tumors was increased during tumor progression from precursor lesions into carcinomas both in epithelial and stromal cells
Nuclei of benign tumors were negative for Snail1
In borderline tumors, occasional positive epithelial cells were found in 2 samples and in 3 samples stromal cells were focally positive for Snail1
In carcinomas, focal Snail1 staining in epithelial cells was present in 17 tumors, and in stromal cells in 18 tumors
Nuclear expression of Snail1 in epithelial or stromal cells was not associated with clincopathologic factors or prognosis

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