Oncology Medical News about acute lymphoblastic leukaemia

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Extended triple intrathecal therapy in children with T-cell acute lymphoblastic leukaemia: a report from the Israeli National ALL-Studies
British Journal of Haematology, 08/21/09

Stark B et al. – Outcome of T–ALL MR patients given extended TIT in the context of BFM–based protocols with long–term follow–up appeared to be comparable to studies in which a larger proportion of patients was irradiated, and was associated with low risk of CNS relapse, regardless of the WBC.

Exclusive Author Commentary
Batia Stark, 08/23/09

For childre with T-ALL - good early prednison responders - regardless of their WBC, extended triple intrathecal therapy in the context of the intensive BFM-based protocols did not compromise outcome, and was comparable to studies in which preventive cranial radiation (pCRT) was administered to a wider proprtion of patients. It seems reasonable to exclude pCRT in the majority of T-ALL patients and thereby spare them its long term side effects.

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Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
British Journal of Haematology, 10/05/09 Relevance Score: 81%

Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993
British Journal of Haematology, 11/04/09 Relevance Score: 80%

Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups – a UKALLXII study
British Journal of Haematology, 11/11/09 Relevance Score: 79%

Prognostic relevance of TLX3 (HOX11L2) expression in childhood T-cell acute lymphoblastic leukaemia treated with Berlin–Frankfurt–Münster (BFM) protocols containing early and late re-intensification elements
British Journal of Haematology, 10/16/09 Relevance Score: 79%

Incidence and reasons for late failure after allogeneic haematopoietic cell transplantation following BuCy2 in acute myeloid leukaemia
British Journal of Haematology, 10/16/09 Relevance Score: 67%