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Denosumab in men receiving androgen-deprivation therapy for prostate cancer
New England Journal of Medicine, 08/26/09
Smith MR et al. – Denosumab in men receiving androgen-deprivation therapy for prostate cancer
Methods- Double-bline, multicenter study
- 734 patients (in each group) were randomly assigned to received densoumab (60 mg sc q6 mos) or placebo
- At 24 mos, BMD of the lumbar spine increased by 5.6% in the denosumab group vs. a 1.0% loss in the placebo group
- Significant differences occurred as early as 1 mo and were sustained through 36 mos
- Denosumab tx increased BMD at the total hip, femoral neck, and distal 1/3 of the radius
- Patients txd with denosumab had a decreased incidence of new vertebral fractures at 36 mos
- Adverse events in the two groups were similar
Today in Bone/Cartilage...keeping you current
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Multidisciplinary treatment including sorafenib stabilized the bone metastases of renal cell carcinoma in an immunosuppressed renal transplant recipient
International Journal of Clinical Oncology, 10/30/09
Endoprosthetic proximal femur replacement: Metastatic versus primary tumors
Surgical Oncology, 11/05/09
Toxicity of Bisphosphonates
Journal of Palliative Medicine, 11/23/09
Today in Endocrine Oncology...keeping you current
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Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
Thyroid, 10/30/09
Thyroid lymphoma and airway obstruction – is there a rationale for surgical management?
International Journal of Clinical Practice, 10/19/09
Thyroid Cancer in Systemic Lupus Erythematosus: A Case-Control Study
Journal of Clinical Endocrinology and Metabolism, 11/12/09
Today in Renal/Urologic...keeping you current
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Upfront, randomized, phase II trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma
Cancer, 11/03/09
Risk of dying from prostate cancer in men randomized to screening
Cancer, 10/13/09
Survivin as a prognostic marker for urothelial carcinoma of the bladder: A multicenter external validation study
Clinical Cancer Research, 11/17/09
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