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See Latest ArticlesEffect of exercise on postmenopausal sex hormone levels and role of body fat: A randomized controlled trial
Journal of Clinical Oncology, 08/25/09
Monninkhof EM et al. - Study confirms that fat loss is associated with changes in postmenopausal sex hormone levels and suggests that exercise may be effective in inducing favorable changes in these hormones
Methods- Main objectives of this study were to examine:
- Effects of a 1-yr exercise intervention on sex hormone levels in postmenopausal women, and
- Whether any effects are mediated by changes in body fat composition
- 189 sedentary postmenopausal women (age 50-69 yrs, BMI of 22 to 40 kg/m2) assigned to an exercise intervention (n=96) or a control group (n=93)
- Intervention combined aerobic and strength training and comprised supervised group sessions and home-based exercises
- Between-group differences in sex hormone levels at baseline and 4 and 12 mo were examined
- 97% women completed the study
- Overall, the exercise intervention did not result in favorable effects on sex hormone levels
- Among women who lost >2% body fat, declines in all estrogens were not different between exercisers and controls
- Androgen levels decreased significantly in the exercise group who lost body fat vs their peers in the control group
- Fat loss was associated with declines in postmenopausal estrogen levels
- Although not significant, a similar trend was observed for the androgens
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