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See Latest ArticlesBaseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials
The Lancet Oncology - Online First, 08/24/09
Quinten C et al. - Data suggest that health-related quality of life (HRQOL) scales provide prognostic information in addition to that of sociodemographic and clinical measures; HRQOL data can help to predict survival in patients with cancer.
Methods- Study examines whether HRQOL scores are associated with survival when pooled across a large sample of pts with different disease sites
- 30 trials from the EORTC started between 1986-2004 were included; provided survival data for 10,108 pts with 11 different cancer sites
- Pts were eligible for inclusion if they had completed a baseline HRQOL assessment
- Sociodemographic variables were age (≤60 vs >60 yrs) and sex, and clinical variables, distant metastases, and cancer site
- Prognostic significance of sociodemographic and clinical variables, and the 15 QLQ-C30 scales with Cox proportional hazard models were assessed
- HRQOL parameters of physical functioning, pain, and appetite loss provided significant prognostic information in addition to the parameters age, sex, and distant metastases, but not for WHO performance status
- Consideration of the 3 HRQOL parameters and sociodemographic and clinical data increased the predictive accuracy of prognosis of overall survival by 6% vs sociodemographic and clinical characteristics alone
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