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Positron emission tomography in staging early lung cancer
Annals of Internal Medicine, 08/26/09
Maziak DE et al.Pre-operative staging with PET-CT and cranial imaging identifies more patients with mediastinal and extrathoracic disease than conventional staging, but resulted in an upstaging of disease in more patients
Methods- Randomized clinical trial
- 8 hospitals and 5 PET/CT academic centers
- Stage I, II, or IIIA resectable NSCLC
- PET/CT or conventional staging, and cranial imaging with CT or MRI
- PET/CT (n=170)
- Conventional (n=167)
- Correct upstaging in 23/167 PET/CT
- Correct upstaging in 11/162 conventional
- Incorrect upstaging in 8 PET/CT
- Incorrect upstaging in 1 conventional
- Understaging in 25 PET/CT
- Understaging in 48 conventional
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