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See Latest ArticlesTid1 functions as a tumour suppressor in head and neck squamous cell carcinoma
The Journal of Pathology, 08/20/09
Chen CY et al. - In a study to investigate the anti-tumourigenic activity of tumourous imaginal disc (Tid1) in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo, these findings suggest that Tid1 functions as a tumour suppressor in HNSCC tumourigenesis.
Methods- The clinical association between Tid1 expression and progression of HNSCC was explored.
- Expression of Tid1 was negatively associated with tumour status, recurrence, and survival prognosis using immunohistochemical analysis of primary HNSCC pt tumour tissue.
- Ectopic expression of Tid1 in HNSCC cells was shown to significantly inhibit cell proliferation, migration, invasion, anchorage-independent growth, and xenotransplantation tumourigenicity.
- It was shown that overexpression of Tid1 attenuated EGFR activity and blocked activation of AKT in HNSCC cells, which are known to be involved in regulation of survival in HNSCC cells.
- Ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression.
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