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See Latest ArticlesEGFR and KRAS status of primary sarcomatoid carcinomas of the lung: Implications for anti-EGFR treatment of a rare lung malignancy
International Journal of Cancer, 08/20/09
Italiano A et al. - In a trial to investigate the use of epidermal growth factor receptor (EGFR)-targeted therapies in pts with primary sarcomatoid carcinomas (SC), it was concluded that the consistent EGFR protein overexpression and high rate of KRAS mutation may contribute to poorer outcome of lung SC in comparison with typical non-small cell lung cancer (NSCLC). The rare incidence of increased EGFR gene copy number, the lack of EGFR mutation, and high rate of KRAS mutation suggest that most pts with lung SC are not likely to benefit from anti-EGFR therapies.
Methods- The status of 4 EGFR pathways biomarkers was analyzed in a series of lung SC.
- EGFR protein expression, EGFR gene copy number, EGFR mutational status, and KRAS mutational status were assessed in 22 consecutive cases of primary lung SC.
- EGFR protein overexpression was observed in all the cases.
- High level of polysomy (4 copies of the gene in >40% of cells) was detected in 5 cases (23%).
- No EGFR mutation was detected.
- KRAS mutations were found in 8 pts (38%; Gly12Cys in 6 cases and Gly12Val in 2 cases).
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Today in Basic Science/Genetics...keeping you current
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Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia
Haematologica, 12/20/09
The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation
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Today in Lung/Thoracic Oncology...keeping you current
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Gene Expression Profiles in Peripheral Blood Mononuclear Cells Can Distinguish Patients with Non–Small Cell Lung Cancer from Patients with Nonmalignant Lung Disease
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A small-cell lung cancer genome with complex signatures of tobacco exposure
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CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients
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