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Selective upregulation of interleukin-8 by human rhabdomyosarcomas in response to hypoxia: Therapeutic implications
International Journal of Cancer, 08/19/09
Wysoczynski M et al. – The authors noticed that such RMS cells, if injected into skeletal muscles of immunodeficient mice, have a reduced ability for tumor formation. They conclude that IL–8 is a pivotal proangiogenic factor released by human RMS cells in hypoxic conditions and that the targeting of IL–8 may prove to be a novel and efficient strategy for inhibiting RMS growth.
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