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Postoperative radiation therapy after complete resection of thymoma has little impact on survival
Cancer, 08/20/09

Utsumi T et al. - In a study to determine the impact of postoperative radiation therapy after complete resection of thymoma, it was concluded that surgical resection alone is sufficient for thymoma pts with Masaoka stage I and II, and those with WHO cell types A, AB, and B1. An optimal treatment strategy should be established for pts with Masaoka stage III/IV and WHO cell type B2/B3 thymomas.

Methods

Records of 324 pts (ages 17-83 yrs; 160 males and 164 females) who underwent complete resection of a thymoma were reviewed.
Mediastinum postoperative radiation therapy was performed for 134 pts.
Survival rates and patterns of recurrence were determined according to Masaoka stage and WHO cell type.

Results

10-yr disease-specific survival (DSS) rates for pts with and without postoperative radiation therapy were 92.8% and 94.4%, respectively.
Subset analyses after stratifying by Masaoka stage and WHO cell type demonstrated that 10-yr DSS rate for pts without postoperative radiation therapy with Masaoka stage I and II, as well as those with WHO cell types A, AB, or B1, was 100%, which was satisfactory.
Rates for pts with Masaoka stage III/IV and those with WHO cell types B2/B3 with or without postoperative radiation therapy were not significantly different.
In 24 pts with disease recurrence, pleural dissemination was observed most often, followed by distant metastases; local disease recurrence without other recurrence occurred in 2.

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