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See Latest ArticlesInhibition of Insulin-Like Growth Factor 1 Receptor by CP-751,871 Radiosensitizes Non–Small Cell Lung Cancer Cells
Clinical Cancer Research, 08/20/09
Iwasa T et al. – The results show that CP–751,871 sensitizes NSCLC cells to radiation both in vitro and in vivo, and that this effect of CP–751,871 is likely attributable to the inhibition of DNA repair and enhancement of apoptosis that result from attenuation of IGF–IR signaling. Combined treatment with CP–751,871 and radiation thus warrants further investigation in clinical trials as a potential anticancer strategy.
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Today in Basic Science/Genetics...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
Clinical Cancer Research, 12/11/09
Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma
Clinical Cancer Research, 12/11/09
Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation
British Journal of Haematology, 12/11/09
Today in Lung/Thoracic Oncology...keeping you current
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Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer
Investigational New Drugs, 12/11/09
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Cancer Chemotherapy and Pharmacology, 12/11/09
Stage I nonsmall cell lung cancer in patients aged >=75 years
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