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Harradine KA et al. – Observation of elevated P–Smad2 levels in transplant recipients is consistent with the notion that elevated TGF–beta signaling may contribute to malignancy in organ transplant recipients. Disparate P–Smad1/5/8 expression levels between keratoacanthoma from the two patient groups might reflect the distinct BMP–responsive cell of origin for this hair follicle–derived lesion.

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