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See Latest ArticlesOverexpression of Protease-Activated Receptor-1 Contributes to Melanoma Metastasis via Regulation of Connexin 43
Cancer Research, 08/17/09
Villares GJ et al. – The authors report that up–regulation of PAR–1 expression, seen in melanoma progression, mediates high levels of Cx–43 expression. As both SP–1 and AP–1 transcription factors act as positive regulators of Cx–43, data provide a novel mechanism for the regulation of Cx–43 expression by PAR–1. Indeed, Cx–43 expression was restored following PAR–1 rescue in PAR–1–silenced cells.
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Today in Basic Science/Genetics...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
Clinical Cancer Research, 12/11/09
Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma
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Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation
British Journal of Haematology, 12/11/09
Today in Dermatologic Oncology...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
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Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
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