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Gastric cancer risk predisposition and prognostic significance of vascular endothelial growth factor (VEGF) gene polymorphisms - A case-control study in an Omani population
Molecular Carcinogenesis, 08/20/09

Al-Moundhri MS et al. - In a trial to investigate the associations between vascular endothelial growth factor (VEGF) gene polymorphisms and gastric cancer (GC) risk predisposition and prognostic characteristics in an Omani population, it was reported that VEGF polymorphisms have no role in GC risk predisposition, but may have prognostic significance in GC pts.

Methods

3 VEGF polymorphisms (+405 G/C, -460 T/C, and +936 C/T) were analyzed by the extraction of genomic DNA from peripheral blood of 130 GC pts and 130 control subjects followed by VEGF genotyping using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis.

Results

There were no significant associations between the VEGF polymorphisms and GC risk.
There were significant correlations between the +405 C/C genotype and both poor tumor differentiation and lymph node metastasis and between the -460 T/T genotype and poor tumor differentiation with a statistical trend toward lymph node involvement.
VEGF gene polymorphisms had no significant effects on survival, but VEGF +405 G/G genotype had a statistical trend toward lower survival rate with a hazard ratio of 1.6 vs the VEGF +405 CC/GC combined genotype.
Multivariate analysis showed that disease stage at diagnosis and +405 G/G genotype were independent variables of adverse prognostic significance.
There were no associations between the 6 common haplotypes identified and both GC risk predisposition and survival.

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