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Yazawa T et al. – These findings suggest that 1) SCLC has an IGFBP–2 overexpression mechanism distinct from NSCLC, 2) secreted IGFBP–2 contributes to the slow growth of SCLC in vitro, and 3) the epigenetic alterations in the IGFBP–2 promoter contribute to the striking differences in IGFBP–2 expression between SCLC and NSCLC in vivo.

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