Oncology Medical News about Melatonin, glioma cells, TRAIL-induced cell death

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Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death
Cancer Letters, 08/18/09

Martín V et al. - In a study to assess the association between melatonin and cell sensitivity to TRAIL-induced cell apoptosis in human glioma cells, it was shown that melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death.

Methods

Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL).
Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens.

Results

It was found that melatonin effectively increases cell sensitivity to TRAIL-induced cell apoptosis in A172 and U87 human glioma cells.
The effect seems to be related to a modulation of PKC activity which in turns decreases Akt activation leading to an increase in death receptor 5 (DR5) levels and a decrease in the antiapoptotic proteins survivin and bcl-2 levels.

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