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See Latest ArticlesTumour infiltrating lymphocytes in squamous cell carcinoma of the oro-and hypopharynx: Prognostic impact may depend on type of treatment and stage of disease
Oral Oncology , 08/19/09
Distel LV et al. - In a trial to evaluate the prognostic influence of various subtypes of tumour infiltrating lymphocytes (TIL) in head and neck cancer (HNC) and the potential influence of regulatory T cells (Treg) in relation to different treatment modalities, it was concluded that the impact of TIL on prognosis in pts with HNC may be affected by type of treatment and stage of disease.
Methods- 115 pts with squamous cell carcinoma (SCC) of the oro- and hypopharynx were selected.
- A low-risk group of 62 pts with early disease was treated by primary surgery followed by external radiotherapy.
- A high-risk group of 53 inoperable pts with advanced disease was treated by primary radiochemotherapy.
- 240 biopsy samples were evaluated using the tissue-micro-array technique employing the following markers: CD3, CD4, CD8, CD20, CD68, FOXP3, Granzyme B.
- In the low-risk group, high CD20+ infiltration was associated with a significantly better NED-survival rate.
- Among high-risk pts low CD20+ counts indicated significantly better survival.
- In the low-risk group higher numbers of intraepithelial CD8+ TIL (>66.6‰) led to improved NED-survival of 95% vs 52%.
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