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Chromogranin-A and N-terminal pro-brain natriuretic peptide: an excellent pair of biomarkers for diagnostics in patients with neuroendocrine tumor
Journal of Clinical Oncology, 08/17/09

Korse KM et al. - In a trial to examine the diagnostic value of chromogranin-A (CgA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) for carcinoid heart disease (CHD), and their prognostic value for overall survival (OS) in neuroendocrine tumor (NET) pts, it was shown that NT-proBNP and CgA are very important markers in diagnosis of CHD in pts with NET. Pts with elevated NT-proBNP in addition to elevated CgA levels showed worse OS than pts with elevated CgA alone.

Methods

Serum samples were obtained and cardiac ultrasound studies performed in 102 NET pts.
The criterion for mild and severe CHD was tricuspid regurgitation stage I/II and III/IV, respectively.
Proportional odds and Cox proportional hazards models were constructed respectively to identify the association between CHD and OS with pt characteristics and the 2 markers.

Results

Severe CHD was found in 15 (15%) of 102 pts, 13 of whom had elevated NT-proBNP levels.
In the univariate proportional odds model, CHD was correlated with age, CgA, and NT-proBNP, whereas in the multivariate model NT-proBNP and CgA were significantly associated with CHD.
In the univariate Cox models, age, sex, CgA, and NT-proBNP were related to OS; and in the multivariate model CgA and NT-proBNP remained significantly related to OS.

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