Oncology Medical News about anti-epileptic drugs, malignant glioma

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Use of peri-operative anti-epileptic drugs in patients with newly diagnosed high grade malignant glioma: a single center experience
Journal of Neuro-Oncology, 08/14/09

Lwu S et al. - In a study to examine peri-operative anti-epileptic drugs (AED) practice patterns in newly-diagnosed pts with malignant glioma to determine if there is deviation from published guidelines, it was found that pts receiving peri-operative AED prophylaxis were common, had a trend to reduced peri-operative seizures, and had few adverse effects. Most pts were maintained on prophylactic AED continued beyond the first peri-operative week, contradicting published guidelines. Increased awareness of practice guidelines may help modify AED prescription patterns in malignant glioma pts.

Methods

A retrospective chart review was performed in adult pts with newly diagnosed malignant gliomas undergoing surgery.
Demographic information, AED use, seizure incidence, adverse effects, tumor size, and tumor location were recorded.

Results

Of 164 eligible pts, 54 (33%) presented with seizures and all received AED.
Prophylactic AED were given to 44 pts (27%).
Peri-operative seizures (within 1 wk) occurred in 2 pts without (3%) and no pts with seizure prophylaxis.
Adverse AED reactions and adverse effects attributable to seizures were both rare.
Prophylactic AED were continued >1 wk post-op in 30 pts (18%).
Pts receiving prophylactic AED were more likely to have had tumors involving the temporal lobe than those who did not (50 vs 20%.

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