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See Latest ArticlesHuman papillomavirus in oral leukoplakia is no prognostic indicator of malignant transformation
Cancer Epidemiology, 08/13/09
Wang SW et al. - In a study to analyze both the human papillomavirus (HPV) status and the genotype in a single individual who develops oral squamous cell carcinoma (OSCC) from pre-existing oral leukoplakia, it was found that HPV in oral leukoplakia is no prognostic indicator of malignant transformation.
Methods- HPV status, genotype, and clinicopathological risk factors were surveyed in cases of malignant transformation from pre-existing oral leukoplakia.
- HPV genomic DNA was detected by PCR (MY09/MY11 in conjugation with nested primer-GP05+/GP06+) from paraffin sections, and genotype was determined by direct DNA sequencing.
- Fisher's exact test and logistic regression were used to analyze risk factors for malignant transformation of oral cavity leukoplakia.
- 167 pts with oral leukoplakia were enrolled; including 12 who had malignant transformation from pre-existing oral leukoplakia.
- HPV prevalence was 22.8% in cases with oral leukoplakia.
- The risk factor associated with malignant transformation was recurrence of leukoplakia after treatment, nevertheless, HPV status was not statistically significant by logistic regression analysis.
- Among the 12 pts with malignant transformation from pre-existing oral leukoplakia, the status or genotype of HPV was chaotic; the oral habits of these pts might contribute to malignant transformation.
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