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See Latest ArticlesVitamin D receptor variants and the malignant melanoma risk: A population-based study
Cancer Epidemiology, 08/13/09
Gapska P et al. - In a study to identify low-penetrance genes that are associated with an increased susceptibility to common types of cancer including malignant melanoma (MM), it was determined that to answer the question, whether vitamin D receptor (VDR) can be regarded as melanoma susceptibility gene, additional, large multi-center association studies must be performed.
Methods- The association was examined between 4 VDR common variants (rs1544410, rs731236, rs10735810, rs4516035) and risk of melanoma in the Polish population.
- Prevalence of compound carriers of VDR and known MM genetic risk factors MC1R and CDKN2A (A148T) variants were determined.
- 763 unselected melanoma cases, 763 healthy adults matched for sex and age were examined with melanoma cases and 777 newborns.
- None of the VDR variants alone or as compound carriers of 2 or more of the VDR genotypes were associated with MM risk.
- There were no major differences between prevalences of the examined variants among pts with MM on UV-exposed and UV-non-exposed skin areas, as well as among early-onset and late-onset cases.
- No association was found between VDR and MC1R or between VDR and CDKN2A common variants.
- A statistically significant over-representation of 1 VDR haplotype: rs731236_A+rs1544410_T was detected.
- Linkage disequilibrium of rs1544410 and rs731236 was confirmed.
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