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See Latest ArticlesProspective evaluation of oral mucositis in acute leukemia patients receiving chemotherapy
Supportive Care in Cancer, 08/13/09
Ramírez-Amador V et al. - In a study to characterize clinical features, associated risk factors, and behavior of oral mucositis (OM) in a cohort of acute leukemia (AL) pts starting chemotherapy (CT), it was determined that OM is a frequent and early side effect of CT closely correlated with oral pain, difficulty to swallow, and impairment in food intake.
Methods- Pts older than 15 yrs of age with AL, scheduled to receive CT, were followed.
- At baseline and 3 times per wk, for 21 days, pts had an oral examination performed using the Oral Mucositis Assessment Scale (OMAS); also, oral pain and difficulty to swallow were recorded using a visual analog scale.
- Wkly, salivary flow measurements (Schirmer’s test modified version) were done.
- 29 AL pts were followed for a median of 21 (range, 14–53) days; 12 (41.4%) developed OM, with a mean OMAS score of 0.181 and a mean peak OMAS score of 1.8.
- OM onset mean time was 9.8 (range, 2–20) days, with a mean duration of 7 (range, 3–14) days.
- OM was significantly correlated with salivary flow, oral pain, ability to swallow, and type of food intake.
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