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Akagi T et al. – Transfection and stable expression of BNC2 caused growth arrest of OE33 EAC cells, suggesting that BNC2 functions as a tumor suppressor gene in the esophagus and that deletion of this gene occurs during the development of EAC. Thus, this SNP–chip analysis has identified several early cytogenetic events and novel candidate cancer–related genes that are potentially involved in the evolution of BE to EAC.

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