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See Latest ArticlesIntracranial low-grade gliomas in adults: 30-year experience with long-term follow-up at Mayo Clinic
Neuro-Oncology, 08/11/09
Schomas DA et al. – A substantial proportion of patients have a good long–term prognosis after GTR and rSTR, with nearly half of patients free of recurrence 10 years after diagnosis. Postoperative RT was associated with improved OS and PFS and is recommended for patients after subtotal resection or biopsy.
Nadia N. Laack, 08/12/09
| Because median survival for patients with low-grade gliomas is long (7-10 years), long-term follow up is essential to understand the both the natural history and the effects of therapy. This report helps physicians determine in which patients the benefits of radiotherapy outweigh the risks. Based on this report, it is our practice to withold radiation for patients with a gross or near-gross total resection until progression (symptomatic or radiologic). However, in patients with subtotal resection, witholding radiation may compromise survival, thus radiation is generally recommended in these patients. The cognitive and neurologic impact of tumor progression is expected to be greater than the risk of radiation effects on cognition in patients with significant residual disease. |
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