Oncology Medical News about Esophageal cancer; radiotherapy; C-reactive protein (CRP)

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Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy
Radiotherapy and Oncology, 08/06/09

Wang CY et al. - In a study to evaluate if C-reactive protein (CRP) is an objective biomarker of esophageal cancer (EC) in pts undergoing radiotherapy, it was revealed that pretreatment serum levels of CRP and albumin are objective, easily measurable biomarkers that can be used in combination with conventional staging to accurately predict survival in pts with EC treated with radiotherapy.

Methods

123 pts undergoing radiotherapy for newly diagnosed EC were enrolled.
Serum CRP concentration was measured before initiation of treatment.
The relationship between serum CRP levels and other relevant variables such as body mass index, white blood cell count, platelet count, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), cholesterol, hemoglobin, and albumin levels was analyzed.

Results

81 of 123 pts enrolled (65.9%) had elevated CRP levels (≥5 mg/L).
2-yr survival for pts with CRP ≥5 mg/L was 7.8% vs 78.4% for pts with CRP <5 mg/L.
Hypoalbuminemia (albumin <3.5 g/dL) was also related to shorter survival using univariate analysis.
Multivariate analysis demonstrated that only higher serum CRP concentration and hypoalbuminemia were independent prognostic indicators for survival of pts with EC.

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