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Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure
Oral Oncology , 08/06/09

Cheong SC et al. - In a study to compare the gene expression patterns of oral cancers associated with betel quid (BQ) chewing to those caused by smoking, it was determined that different carcinogens activate or inhibit specific pathways during cancer development and progression. These unique gene expression profiles should be taken into consideration when developing biomarkers for future use in prognostic or therapeutic applications.

Methods

The gene expression patterns of oral cancers associated with BQ chewing were compared with those caused by smoking using Affymetrix microarrays.

Results

281 genes were differentially expressed between OSCC and normal oral mucosa regardless of aetiological factors including MMP1, PLAU, MAGE-D4, GNA12, IFITM3 and NMU.
168 genes were identified that were differentially expressed between the BQ and smoking groups including CXCL-9, TMPRSS2, CA12 and RNF24.
Expression of these genes was validated using qPCR using independent tissue samples.
While common genes/pathways contribute to development of oral cancer, there are also other gene expression changes that are specific to certain risk factors.

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