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See Latest ArticlesAge as a determinant of outcomes for patients with oral cancer
Oral Oncology , 08/06/09
Goldenberg D et al. - In a study to determine whether survival outcomes of younger pts with oral cavity squamous cell cancer (OSCC) differs from older pts in the US, these results confirm recent results using population-based data that suggest better overall survival in younger pts.
Methods- A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry.
- Cases (n=19681) of OSCC diagnosed from 1973 to 1999 were studied and age cutoffs were used at 40, 45, 50, and 55 yrs.
- Control groups of older pts were retrospectively matched on gender, race, cancer subsite, and stage of disease.
- Survival was estimated using the Kaplan–Meier method.
- A propensity score matching produced groups with similar distributions of pt and disease characteristics.
- Between these matched groups, younger pts had a significantly better 5-yr survival (age 40: 63.4% vs 80.6%; age 45: 59.0% vs 72.8%; age 50: 55.5% vs 67.2%; age 55: 54.0% vs 64.3%).
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