Oncology Medical News about bone metastases; radiation fields; pain relief

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Would larger radiation fields lead to a faster onset of pain relief in the palliation of bone metastases?
International Journal of Radiation Oncology*Biology*Physics, 08/11/09

Chow E et al. – In a study to examine whether there is a relationship between areas of radiation treatment and onset of pain relief, it was concluded that there was no statistical significance between mean areas of radiation treatment with the onset of pain relief.

Methods

653 pts with symptomatic bone metastases were treated with external beam radiation.
Pain scores and analgesic consumption were recorded at baseline and weeks 1, 2, 4, 8, and 12.
Areas of radiation treatment for all pts were calculated, then correlated with the response and analyzed in various ways.
First, pain score alone was compared with mean radiation field size.
Second, pain score and analgesic consumption were combined.
Last, the International Consensus endpoints for pain score and analgesic intake were implemented.

Results

Assessment of 653 pts showed no significant correlation comparing pain scores alone with radiation field area, with the exception of week 4 for partial responders.
No significant correlation was found when combining both analgesic intake and pain score against radiation field size.
Even when implementing the International Consensus endpoint definitions for radiation response, the only significant correlation between radiation field size and response was observed in week 2 for partial response.

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