Oncology Medical News about chronic myeloproliferative neoplasm

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Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm
Human Pathology, 08/10/09

Tang G et al. – The authors report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression.

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Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms
British Journal of Haematology, 11/11/09 Relevance Score: 67%%

AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
Blood, 11/09/09 Relevance Score: 67%%

Co-treatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplasm cells
Blood, 11/02/09 Relevance Score: 66%%

Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Clinical Cancer Research, 11/09/09 Relevance Score: 65%%

Chronic idiopathic myelofibrosis with myeloid metaplasia presenting as refractory ascites
Pediatric Blood & Cancer, 10/19/09 Relevance Score: 65%%