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Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients
Cancer Chemotherapy and Pharmacology, 08/05/09
Fidlerova J et al. – The results indicate that missense and nonsense variants in DPYS are infrequent, however, the development of serious primarily gastrointestinal toxicity could be influenced by non–coding DPYS sequence variants c.–1T>C and IVS1–58T>C.
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Unanticipated toxicities from anticancer therapies: Survivors perspectives
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