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Autologous Melanoma Vaccine Induces Antitumor and Self-Reactive Immune Responses That Affect Patient Survival and Depend on MHC Class II Expression on Vaccine Cells
Clinical Cancer Research, 08/04/09
Lotem M et al. – Autologous melanoma cell vaccine is capable of inducing effective antimelanoma CD4 T–cell activity associated with improved survival. Patients with active metastatic disease generally displayed reduced immune response and gained little from active immunization.
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